However, there is evidence that some craniosynostosis genes also regulate whole-body bone homeostasis, such as mutations in LRP5 causing osteoporosis-Pseudoglioma, ALPL causing low serum alkaline phosphatase, and low-BMD, PHEX leading to hypophosphatemia rickets and diminishing bone regenerative capacity (79), etc. Moreover, all known craniosynostosis causative genes are also identified by GWAS for human height (msk.hugeamp.org), suggesting the role of bone growth in the etiology of the condition. Here, LRP5 is linked to craniosynostosis.