FNDC5 and metabolic dysfunction-associated steatotic liver disease: A recent study has revealed that exercise-induced irisin competitively inhibits the binding of myeloid differentiation factor 2 (MD2) and Toll-like receptor 4 by forming a complex with MD2 in liver cells and thus inhibits the inflammatory response, which may contribute to the improvement of NAFLD by reducing liver steatosis and fibrosis through exercise (34).