A recent study has revealed that exercise-induced irisin competitively inhibits the binding of myeloid differentiation factor 2 (MD2) and Toll-like receptor 4 by forming a complex with MD2 in liver cells and thus inhibits the inflammatory response, which may contribute to the improvement of NAFLD by reducing liver steatosis and fibrosis through exercise (34). This evidence concerns the gene LY96 and metabolic dysfunction-associated steatotic liver disease.