As a key energy sensor to maintain energy balance and mitochondrial hemostasis (131), AMPK mediated the effect of FNDC5/irisin on mitophagy, oxidative stress, and mitochondrial biogenesis, thereby improving myocardial hypertrophy, myocardial infarction, atherosclerosis, and other cardiac diseases, which reflecting the protection of regular exercise on cardiac health. This evidence concerns the gene FNDC5 and atherosclerosis.