found that the receptor of irisin also existed on the surface of PC cells; supplementation of both non-glycosylated and glycosylated r-irisin in PCs could induce G1 arrest and inhibit the growth of PC via activating AMPK and inhibiting mTOR expression (110); these results indicate that irisin can affect tumor tissues and exert antitumor properties. The gene discussed is FNDC5; the disease is pachyonychia congenita.