Similarly, high expression of STAT3 was found in the nucleus of endometrioid adenocarcinoma [24], high expression of p-STAT3 was found in the nucleus of hepatocellular carcinoma [25], and high expression of STAT3 and p-STAT3 was found in the cytoplasm and nucleus of breast cancer [26]. This evidence concerns the gene STAT3 and hepatocellular carcinoma.