In the high-risk group, enriched pathways involved glycosaminoglycan-biosynthesis-chondroitin-sulfate, ecm-receptor-interaction, dilated-cardiomyopathy, gap-junction, arrhythmogenic-right-ventricular-cardiomyopathy-arvc, focal-adhesion, vascular-smooth- muscle-contraction, melanoma, hypertrophic-cardiomyopathy-hcm, regulation-of-actin-cytoskeleton, renin-angiotensin-system, melanogenesis, neuroactive-ligand-receptor-interaction, calcium-signaling-pathway, and long-term-depression. Here, REN is linked to hypertrophic cardiomyopathy.