Following intervention with CHSSC or the CaMKII inhibitor KN-93, the levels of CaMKII, p-CaMKII, and RyR2, were significantly lower than those in the model group, but higher than those in the sham operation group, which indicated that both CHSSC and CaMKII inhibitor KN-93 down-regulated the expression of CaMKII, p-CaMKII, RyR2, and p-RyR2 in myocardial tissue of rats with myocardial ischemia. Here, CAMK2G is linked to myocardial ischemia.