These studies and our data showed that activated CaMKII can regulate the affinity of the FKBP12.6-RyR2 complex through phosphorylation of RyR2 (Ser2814) and/or RyR2 (Ser2808), and CHSSC may reduce phosphorylation of RyR2 (Ser2814) and/or RyR2 (Ser2808) (mainly RyR2 Ser2808) through inhibition of the activation of CaMKII following myocardial ischemia. Here, RYR2 is linked to myocardial ischemia.