Furthermore, activation of the Ser2808 phosphorylation site on RyR2 after myocardial ischemia was significantly inhibited following treatment with CHSSC, while phosphorylation at Ser2814 was not significantly inhibited, and dissociation of the FKBP12.6-RyR2 complex was inhibited. This evidence concerns the gene RYR2 and myocardial ischemia.