We also established a H9C2 cell model of myocardial ischemia to detect changes in intracellular Ca2+ content, the expression of RyR2, and the interaction between FKBP12.6 and RyR2 to evaluate the effects of CHSSC on ventricular arrhythmia after myocardial ischemia through regulation of the CaMKII/FKBP12.6/RyR2/Ca2+ signaling pathway. Here, RYR2 is linked to myocardial ischemia.