Studies have shown that external use of the traditional Chinese medicine compound rhubarb powder exerts a significant effect on relieving joint redness, swelling, heat, and pain in RA patients, and in an RA mouse model, this treatment can reduce the expression of IL-33, MMP-10, TNF-α, and other cytokines and increase the level of IL-10 and the ratio of OPG/RANKL, which results in controlling RA inflammation and preventing the exacerbation of disease [100]. Here, TNF is linked to rheumatoid arthritis.