Obesity and diabetes treatment using the Huanglian Huazhuo capsules was via multiple pathways associated with various pathways, such as AGE-RAGE signaling pathway, fluid shear stress and atherosclerosis, HIF-1 signaling pathway, IL-17 signaling pathway, and TNF signaling pathway in diabetes complications. Here, TNF is linked to obesity due to melanocortin 4 receptor deficiency.