Furthermore, elevated total eIF4E levels, together with 4EBP1 hyperphosphorylation, increased the effectiveness of eIF4E binding to eIF4G and enhanced cap-dependent translationa phenomenon found in breast and prostate carcinomas, while high eIF4E levels were associated with progression-free and overall survival reductions [38, 39]. Here, EIF4G1 is linked to prostate carcinoma.