TLR9 and Sepsis: In this study, sepsis animal models were constructed in TLR9−/− mice and WT mice by CLP to explore the influencing mechanism of myeloid TLR9 on sepsis-induced inflammatory response in vivo, and we also investigate the mechanisms of macrophage-derived exosomes of TLR9−/− mice on sepsis-induced mitochondrial apoptosis in cardiomyocytes in vitro.