TLR9 and Sepsis: We found that in control mice, there were no significant abnormal changes in the heart, mainly exhibited the healthy tissue' morphological structure, whereas in sepsis mice, the WT BMT mice' myocardium showed relatively extensive cellular shrinkage, chromatin condensation, and nuclear fragmentation, and in TLR9−/− BMT mice, these pathological changes were relieved; all these observation indicated that myeloid TLR9 could accelerate the progression of SIC by destroying structures of cell and organelle; all results are shown in Figure 1.