For instance, FUS modulates circHIF1A, which can propel the development of triple-negative breast cancer via targeting NFIB [22]; circSPARC propels p-STAT3 nuclear translocation by recruiting FUS in colorectal cancer (CRC) [23]; circRHOBTB3, which is transcriptionally activated by FUS, stabilizes PTBP1 mRNA to hamper metastasis of CRC [24]; and miR-4319 impairs the processes of thyroid cancer through regulating SMURF1, which is stabilized by FUS [25]. The gene discussed is SMURF1; the disease is colorectal carcinoma.