In ICGC and GSE14520 datasets, it was indicated that the genes of XRCC6, XRCC5, TRIM21, TREX1, TBK1, STING1, STATE6, PRKDC, NRLP4, NLRC3, MRE11, IRF3, DDX41, and cGAS showed higher expression in HCC than the adjacent normal liver group. Here, DDX41 is linked to hepatocellular carcinoma.