More importantly, we divided HCC patients from TCGA, ICGC, and GSE14520 datasets into low- and high-risk subsets based on the best cutoff value of VAV1, RHOA, and ZC3HAV1 expression determined by the K-M method, and found that the EMT scores of survival-related IRCGS in the high-risk group were higher than those within the low-risk group. This evidence concerns the gene ZC3HAV1 and hepatocellular carcinoma.