In ICGC and GSE14520 datasets, it was indicated that the genes of XRCC6, XRCC5, TRIM21, TREX1, TBK1, STING1, STATE6, PRKDC, NRLP4, NLRC3, MRE11, IRF3, DDX41, and cGAS showed higher expression in HCC than the adjacent normal liver group. This evidence concerns the gene PRKDC and hepatocellular carcinoma.