According to five survival-related gene markers within STING pathway including NLRC3, STING1, TBK1, TRIM21, and XRCC6, we constructed a predictive nomogram using the TCGA-training cohort, aiming to provide a quantitative analysis tool to evaluate the survival risk at 1-, 3-, and 5-year for individual patients with HCC (Fig. 3A). This evidence concerns the gene TRIM21 and hepatocellular carcinoma.