In the current study, we comprehensively explore the prognostic value of STING pathway in HCC cohorts obtained from The Cancer Genome Atlas (TCGA, n = 366), Gene Expression Omnibus (GEO, GSE14520, n = 242), and International Cancer Genome Consortium (ICGC, n = 243). The gene discussed is STING1; the disease is hepatocellular carcinoma.