TRIM21 and hepatocellular carcinoma: The result showed that the gene markers of NLRC3 (P < 0.001 in TCGA and P = 0.045 in ICGC database), TRIM21 (P = 0.012 in GSE14520 and P = 0.023 in ICGC cohort), and other three genes included in the ICGC cohort, namely STING1, TBK1, and XRCC6, presented a significant association with prognosis in HCC patients (Fig. 1C, F, and I).