To determine the influence of three survival-related IRCGS on the expression of the prominent immune checkpoint molecules of PD-1, PD-L1, PD-L2, CTLA-4, LAG3, TIGIT, and IDO1, we evaluated the expressed difference of immune checkpoint molecules in HCC samples included in the low- and high-risk group stratified by VAV1, RHOA, and ZC3HAV1 from TCGA and ICGC datasets, separately. The gene discussed is CD274; the disease is hepatocellular carcinoma.