NLRP3 and infection: Similarly, mRNA expression of chemokines cxcl1, cxcl2 and CXC chemokine receptor 2 (cxcr2) which drives the activation of NLRP3 inflammasomes [22], was also significantly decreased in P. multocida-infected Nlrp6−/− macrophages (Figures 5D, E, F) at 3, 6, 9, and 24 h post-infection.