While NLRP6 knockout attenuates IL-6 secretion during Streptococcus pneumoniae and P. multocida, it is likely that NLRP6-mediated IL-1β and IL-6 secretion may exhibit different signaling pathways in response to different pathogen infections, and the exact mechanism of NLRP6-mediated IL-6 secretion needs to be further explored. Here, IL1B is linked to infection.