IL27 and pachyonychia congenita: Since we reported that IL30 expression is tightly linked with advanced PC grade and stage (4), to obtain a cohort of patients in which the number of PC patients with a high level of expression of IL30 was suitable to provide an adequate confidence level (85% power at a 5% significance level), we selected 198 PC patients with Gleason score from 8 to 10 (high-grade tumors) and stage III disease (high-risk, clinically localized PC).