SFRP1 and neoplasm: Treatment with IL30 also upregulated tumor progression genes, such as Ar (3.27 times), Bcl2 (3.25 times), IL6 (3.90 times), Cav2 (7.60 times), Ndrg3 (4.5 times), Sept7 (4.10 times) and Sfrp1 (7.46 times) (Fig. 2A).