In both human PC cell lines, DU145 and PC3, IL30 gene deletion led to a significant downregulation of chemokine receptors, which promote cancer cell migration and metastatic dissemination [48] namely CXCR5 (− 2.81 times), CCR4 (− 11.96 times) and CXCR2 (− 9.07 times) in DU145 cells, and CCR1 (− 2.71 times), CCR10 (− 11.00 times) and CCR2 (− 27.67 times) in PC3 cells (Fig. 5B, C, D). Here, IL27 is linked to cancer.