While confirming the tumor-promoting function of IL30, in both murine syngeneic and human xenograft models of PC, our findings demonstrate the membrane-bound expression of IL30 in human PC cells and unveil the novel mechanisms underlying its ability to boost, via juxtacrine signaling, a complex tumor progression program, which includes downregulation of tumor suppressor genes, such as SOCS3, and upregulation of oncogenes and growth factors, primarily IGF1 and CXCL5. Here, CXCL5 is linked to pachyonychia congenita.