Tumor progression and metastasis, and consequent reduced survival of mice-bearing IL30-overexpressing tumors, could be favored by the prominent upregulation of chemokine receptor expression [35, 48] in murine PC cells, such as Ccr2, Ccr4, Ccr5, Ccr9 and Cxcr5. Consistently, the dramatic downregulation of CCR2, CCR4, CXCR5, CCR1 and CCR10, obtained by CRISPR/Cas9-mediated deletion of IL30, can cooperate in hindering disease progression in IL30 knockout tumor-bearing xenograft. Here, CXCR5 is linked to pachyonychia congenita.