IL27 and pachyonychia congenita: Silencing of STAT1 and STAT3 with specific siRNAs (Additional file 2: Fig. S2C, D) in IL30-overexpressing DU145 and PC3 cells (in which the increase of the phosphorylated isoforms of STAT1 and STAT3 was evident) resulted in a significant (ANOVA: p < 0.05) reduction in their proliferation, migration and invasion abilities, which were comparable to those of wild-type cells (Fig. 2Q, R, S), thus confirming, in human PC cells, the role of the STAT1/STAT3 pathway in IL30 signaling.