In TRAMP-C1 cells, IL30 also boosted an immunosuppressive and tumor immune escape program (Fig. 5A), which includes the upregulation of Ido1 (34.01 times), Nos2 (21.37 times), Ptgs2 (5.93 times) [37], Cd274, which encodes for Pd-l1 (26.50 times), Pdcd1, which encodes for PD-1 (7.56 times), Ctla4 (6.86 times) [38], Tlr2-3-4-9 (2.51, 43.05, 7.61 and 53.36 times, respectively) [39] and, particularly, FasL (80.88 times) [40]. Here, CTLA4 is linked to neoplasm.