IL27 and pachyonychia congenita: Since tumor overproduction of IL30 promoted a substantial intra-tumoral myeloid cell infiltrate, in both xenograft and syngeneic models, and in the latter also an influx of Tregs, whereas the genetic deletion of IL30 in human PC cells dampened inflammation in the tumor microenvironment, we wondered whether IL30 interfered with the cancer-immune cell crosstalk by regulating PC cell expression of immunity genes driving immune cell recruitment.