CXCR2 and neoplasm: Through its interaction with C-X-C chemokine receptor type 2 (CXCR2), CXCL5, also known as epithelial cell-derived neutrophil-activating peptide-78 (ENA-78), regulates neutrophil influx into the inflamed tissues, and stimulates tumor growth and progression directly or via infiltration and activation of granulocytes and MDCs [51, 53, 54].