Accordingly, in IL30 knockout human PC cells, the expression of CCL4 and CCL22 was substantially downregulated, along with the expression of IL12B and IL23A, coding for IL23 that is regulated by IL30 in murine and human PC cells, but also in murine and human breast cancer stem cells resulting in autocrine and paracrine effects [17]. Here, CCL4 is linked to breast carcinoma.