IL27 and pachyonychia congenita: While confirming the tumor-promoting function of IL30, in both murine syngeneic and human xenograft models of PC, our findings demonstrate the membrane-bound expression of IL30 in human PC cells and unveil the novel mechanisms underlying its ability to boost, via juxtacrine signaling, a complex tumor progression program, which includes downregulation of tumor suppressor genes, such as SOCS3, and upregulation of oncogenes and growth factors, primarily IGF1 and CXCL5.