Since neutralization of membrane-bound IL30, inhibits proliferation and invasiveness in human PC cells, while in the mouse model, targeting of the IL30 gene has demonstrated to inhibit murine PC-SLC tumorigenicity, tumor onset and progression [4], we wondered whether IL30 signaling might regulate, in both human and murine PC cells, the network of genes driving PC oncogenesis. Here, IL27 is linked to pachyonychia congenita.