In human PC cells, essential PC driver genes were suppressed following IL30 gene knockout, such as MKI67, which is an established marker of tumor proliferation and an independent predictor of PC death [69], FASN, which modulates PC cell adhesion and migration and has been associates with BCR [70, 71], HMGCR, which is elevated in enzalutamide-resistant PC cells and has been associated with poor prognosis [72], and PTGS2/Cox-2, which catalyzes the rate-limiting steps in prostaglandin biosynthesis and could promote tumor growth and suppress tumor immunity [73]. The gene discussed is HMGCR; the disease is pachyonychia congenita.