SOCS3 and pachyonychia congenita: The immunopathological and morphometric study of PC samples from patients with high-grade and locally advanced disease, which more frequently express IL30 in their clinical samples, determined a significant association between the expression of IL30 and the lack of expression of SOCS3 in the tumor tissues and revealed a higher percentage of patients undergoing progression among those diagnosed with IL30PosSOCS3NegPC, when compared with patients diagnosed with IL30Neg SOCS3PosPC.