CCR4 and cancer: Intriguingly, in TRAMP-C1 cells, IL30 overproduction strongly upregulated the expression of chemokine receptors, namely Ccr1 (35.95 times), Ccr2 (45.50 times), Ccr4 (42.75 times), Ccr5 (51.90 times), Ccr9 (92.27 times) [35] and Cxcr5 (35.95 times) [36], which can promote cancer cell migration and metastatic spread.