DKK3 and pachyonychia congenita: Besides downregulating relevant PC drivers, IL30 gene deletion rehabilitates in both human PC cell types, the expression of critical tumor suppressor genes, which are usually silenced in PC, such as DKK3, a secreted glycoprotein shown to inhibit TGFβ signaling, and primarily SOCS3, which negatively regulates JAK/STAT signaling and prevents cancer cell proliferation, invasion and metastasis [55].