Immunopathological analyses revealed that cytoplasmic and nuclear expression of NFKB1 was relevant in IL30-overexpressing tumors and scanty in IL30KO tumors, in which the expression of tumor suppressors CDH1/E-Cadherin, DKK3, PTEN, RARB and SOCS3, which was also detected in macrophage-like cells, was stronger than in control tumors, while that of PTGS2 was fainter (Fig. 4F), therefore, strengthening the in vitro data on the regulation of PC driver genes by IL30 in human PC cells. The gene discussed is CDH1; the disease is pachyonychia congenita.