To assess whether membrane-bound IL30 can affect, via juxtacrine signaling, neighboring cancer cells, we analyzed their expression of gp130 and CD126, currently known to function as the IL30 receptor chains (8) (Fig. 1G, H), and determined their viability, both after adding neutralizing anti-IL30 Abs to the culture medium (Fig. 1I, J) and following IL30 overexpression (IL30-DU145 and IL30-PC3), obtained by gene transfection (Fig. 1K, L). This evidence concerns the gene IL6R and cancer.