In patients that underwent prostatectomy for locally advanced PC, those diagnosed with IL30Negative tumor showed a favorable immune cell context, characterized by intra-tumoral TIA-1+CD4+T lymphocytes and rare Foxp3+Tregs, and a lower biochemical recurrence rate than patients bearing IL30Positive tumor, in which IL30 was expressed in both tumor cells and infiltrating leukocytes [7]. The gene discussed is IL27; the disease is neoplasm.