Murine PC cells share a significant IL30-dependent upregulation of oncogenes, such as Abcb1a, that confers resistance to chemotherapy [58], Bcl2, that rescues cancer cells from apoptosis and drives androgen-independent growth [59], Cav2, which can activate cellular mitogenesis [60], and Creb1, which regulates a network of genes required for cell survival, proliferation and migration [61]. Here, CREB1 is linked to cancer.