IL27 and neoplasm: PC cell production of IL30 also affected the extent of the intra-tumoral immune cell infiltrate, since macrophages and granulocytes increased in IL30-overexpressing tumor xenograft, compared to controls (ANOVA, p < 0.0001; Tukey HSD test, p < 0.01 vs wt-DU145 and EV-DU145), whereas they were poorly detected in IL30-deficient tumors (ANOVA, p < 0.0001; Tukey HSD test, p < 0.01 vs wt-DU145 and NTgRNA-treated DU145 (Fig. 4G, H).