To evaluate, in vivo, the consequences on PC development of IL30 expression, or targeted deletion, in human PC cells, DU145 cells, which constitutively expressed the highest level of IL30 (Fig. 1A, a), were implanted in NSG (NOD scid gamma) mice, after targeted deletion, or overexpression, of IL30 gene. Here, IL27 is linked to pachyonychia congenita.