PTGS2 and neoplasm: Monitoring of tumor xenografts in mice implanted with human IL30 knockout PC cells, demonstrates that suppression of the constitutive IL30 production slows tumor progression, reduces lung metastases and prolongs survival, whereas concomitant immunopathological analyses confirmed in vivo the downregulation of oncogenes, such as PTGS2 [73] and the upregulation of tumor suppressors, such as CDH1/E-Cadherin [74], PTEN [75], RARB [76], DKK3 [77] and SOCS3 [55, 56].