Of note, periostin promotes chemoresistance through several mechanisms, including: 1-induction of EMT; 2-increased cancer cell stemness; 3-upregulation of LOX and increasing stiffness; 4-activation of Akt and Erk, the PI3K/Akt/survivin, and the PI3K/Akt/survivin pathways. Here, POSTN is linked to cancer.