Although Tai et al. reported that periostin expression significantly increased in colorectal cancer tissue and metastatic liver lesions, they observed unexpected results (negative expression) in RNA expression in a variety of cell lines, including colon cancer (HCT 116, RKO, SW-620, and HT 29), breast cancer (MDA 435, MCF-7), uterine sarcoma (MES-SA, MES-SA/DX5), pancreatic cancer (MIA PaCa-2), except in mesothelioma (JMN1B) and normal colon cell line (CCD-112CoN), that expression was increased [55]. This evidence concerns the gene POSTN and colonic neoplasm.