Dysregulation of periostin expression arises in fibrosis [35, 36, 40–42], wound healing tissues [43–46], inflammatory diseases such as arthritis, atherosclerosis [22, 23, 28], infarcted myocardium [15, 39], tumorigenesis, and metastasis [11, 22, 23, 28]. This evidence concerns the gene POSTN and arthritic joint disease.