AKT1 and adenosquamous carcinoma: In addition to identifying dominant HLA-restricted HPV18 E6/E7 CD8 + T cell epitopes, we generated a spontaneous adenosquamous carcinoma model using LucHPV18E7E6(delD70), AKT, cMyc, and SB100 in HLA-A2 transgenic mice (Fig. 8).