In the current study, we showed that HPV18 positive cervical cancer cell line, Hela, when HLA-A*0201/Dd (AAD) was overexpressed, can be recognized by both HLA-A2-restricted HPV18 E6 peptide (aa97-105) and HPV18 E7 peptide (aa7-15)-specific CD8 + T cells, indicating that these two epitopes can be processed and presented by this HPV18 positive cervical cancer cells. The gene discussed is HLA-A; the disease is cervical cancer.