Thus, co-transfecting the LucHPV18E7/E6(delD70), AKT, cMyc, and SB100 tumor model with DNA encoding one of these immunosuppressive molecules at a time may result in a cervicovaginal tumor model that does not require CD3 depletion and can incorporate aspects of the tumor microenvironment that is seen clinically. The gene discussed is AKT1; the disease is neoplasm.