Further investigation on the effect of 3D matrix on expression levels of various signaling molecules like integrin-linked kinase, mitogen-activated protein kinase (ERK), and phosphoinositide 3-kinase (PI3-K) impacting the activity of anti-apoptotic BCL-2 family proteins, NF-kB, and AKT (forkhead and IAP protein regulators) would be interesting and might provide further insights on cross-talk between lymphoma cells and extracellular matrix [75]. Here, AKT1 is linked to lymphoma.