Genetic alterations in melanoma patients were seen to activate the RAS/RAF/MEK/ERK (MAPK) and the PI3K/PTEN/AKT (AKT) signaling pathways, so that it has been found that the growth of melanoma cells can be blocked as a result of inhibiting both ERK and PI3K signaling [11–13]. Here, MAP2K7 is linked to melanoma.