NSMCE2 and breast carcinoma: Lastly, using the ROC Plotter tool, we found that NSMCE2 high expression levels do not correlate with patients’ response to therapy for ovarian cancer, colorectal cancer, and glioblastoma [47, 48] (data not shown), thus, confirming that high levels of NSMCE2 gene expression are specifically associated with breast cancer patients’ poor response to chemotherapy.