Since NSMCE2 is known to be required for DNA damage repair at different steps of the process and for chromosomal segregation during mitosis [40–42, 49–51], NSMCE2 may inhibit chemotherapy-induced apoptosis, thus contributing to the therapy resistance we observed in breast cancer patients showing high NSMCE2 gene expression. The gene discussed is NSMCE2; the disease is breast carcinoma.