According to previous works using different models of obesity-induced IR, we hypothesized that hyperactivity of both mTORC1 and S6K1 may be induced by greater demand for protein synthesis observed during periods of accelerated growth [20], and may be involved in the physiological desensitization of insulin signaling in organs with high metabolic rate. Here, RPS6KB1 is linked to obesity due to melanocortin 4 receptor deficiency.