With deeper correlation analyses, we found that KLF5 and CXCR4 was positively relative with Vimentin and N-cadherin while they were negative significantly with E-cadherin while the coefficients of KLF5 or CXCR4 among these EMT markers were extremely similar (Fig. 7e), which inspired us whether KLF5 upregulated by circEZH2 promoted EMT of BC in CXCR4 induced way. The gene discussed is CDH2; the disease is breast cancer.