Similarly, when the “Profile-C” expression (i.e., TIM3 (HAVCR2), OX40 (TNFRSF4), GITR (TNFRSF18), TIGIT, LAG3 and PDCD1) was investigated in Testicular Germ Cells Tumor (TGCT) samples, a clear separation from the corresponding controls was found (Fig. 2C), while the same profile does not discriminate LUAD, PRAD and THCA cancer patients from the corresponding controls, indicating that such profile appears to be specific for TGCT patients. Here, TNFRSF4 is linked to cancer.