“Profile-B” is made by the 6 molecules differently expressed in Pancreatic adenocarcinoma (PAAD) patients (i.e., TIM3 (HAVCR2), OX40 (TNFRSF4), GITR (TNFRRSF18), TIGIT, LAG3 and CTLA4). Here, TNFRSF18 is linked to pancreatic adenocarcinoma.