Ubiquitin protein ligase E3 has been associated with tumorigenesis via the stabilization or degradation of target proteins [5, 32], with higher levels of ubiquitin protein ligase E3 with CNVs potentially being associated with tumorigenesis; however, the molecular mechanisms underlying the role of UBR5 in HCC remain unknown. The gene discussed is UBR5; the disease is hepatocellular carcinoma.