In PCF-55 cells, both, PC-EVs and HC-EVs induced the expression of a number of chemokines such as CCL2, CCL13, CXCL1, CXCL8, etc. This finding is consistent with a previous report showing that EVs released by metastatic gastric cancer cells contribute to the generation of a specific subpopulation of CAFs producing CXCL family chemokines [14]. This evidence concerns the gene CXCL8 and gastric cancer.