TLR2 and acute-on-chronic liver failure: Impaired expression of TLR2 and TLR3 was observed in PBMCs isolated from chronic HBV-infected (CHB) patients at both the mRNA and protein levels [16, 31], while increased expression of TLR1/2, TLR2/6, TLR5, and TLR8 has been reported in CD4 + and CD8 + T cells of CHB-related acute-on-chronic liver failure (ACLF) patients [32].