For example, intrahepatic LSECs exert a positive role in improving the amount, function and proliferation of intrahepatic CD8 + T cells in response to TLR2 or TLR5 agonist stimulation [52, 99], while TLR2-stimulated KCs exhibit enhanced suppressive activity against CD8 + T cells by secreting IL-10 [100]. The gene discussed is TLR2; the disease is dry eye syndrome.