It can be observed that GNE987 decreased BRD4 and inhibited tumor growth, and the important organs of nude mice (liver and kidney) had no obvious pathological changes, which suggested that GNE987 can also target and decrease BRD4 to inhibit the growth of GBM tumors without obvious toxicity and side effects, which provides a certain theoretical basis for clinical transformation. This evidence concerns the gene BRD4 and neoplasm.