The expression abundance of S100A16 significantly correlated with the survival probability of glioma patients (Fig. 6g); moreover, H3K27Ac can be used to annotate transcriptionally active chromatin regions [17]; thus, we obtained H3K27Ac ChIP-seq data to map the gene locus of S100A16, and visualized using IGV View Software to characterize the effect of GNE987 on S100A16 (Fig. 6h). Here, S100A16 is linked to glioma.