S100A16 and central nervous system cancer: The expression abundance of S100A16 significantly correlated with the survival probability of glioma patients (Fig. 6g); moreover, H3K27Ac can be used to annotate transcriptionally active chromatin regions [17]; thus, we obtained H3K27Ac ChIP-seq data to map the gene locus of S100A16, and visualized using IGV View Software to characterize the effect of GNE987 on S100A16 (Fig. 6h).