The signalling triggered by the kinase EphA2 leads to FAK-mediated PI3K and ERK1/2 pathway activation, which besides being associated with survival, proliferation and migration are also important in the VM process; in fact, PI3K regulates extracellular matrix remodelling, crucial for VM-forming tumour cell migration, by inducing the activation of MMP-2 (mediated by MMP-14) and MMP-9. The gene discussed is MMP9; the disease is neoplasm.