VE-cadherin expression, whose modulation under hypoxia can be dependent on both the isoforms 1 and 2 of HIF-α (HIF-1α and HIF-2α) [176], is also indirectly increased by hypoxia-induced BNIP3, a protein belonging to Bcl-2 family that contributes to VM by promoting cancer cell migration and cytoskeleton organisation during tube formation [175]. The gene discussed is CDH5; the disease is cancer.