COX-2, the enzyme that converts arachidonic acid into prostaglandin E2 (PGE2), upon binding prostanoid receptors (EP1–4), activates PKC signalling that in turn stimulates VEGF-A expression and subsequent tumour-derived vascular channel formation in glioblastoma, and lung and breast cancer [33]. The gene discussed is VEGFA; the disease is breast carcinoma.