Indeed, as reviewed by Liu and colleagues, along with controlling the E-cadherin/N-cadherin and vimentin levels, Twist, Zeb1, Snail and Slug also modulate VE-cadherin and VEGF-R2 expression, activate MMP-2 and MMP-9, as well as guarantee stemness maintenance in VM‐positive cancer cells [50]. This evidence concerns the gene CDH5 and cancer.