As TUC338 was aberrantly expressed in NPC, to reveal the role of TUC338 in NPC, both CNE-1 and 5-8F cells were transfected with siRNA-TUC338 or siRNA-control, and the knock down efficiency of TUC338 was confirmed as indicated in Fig. 2A. The data of CCK-8 assay demonstrated that depletion of TUC338 significantly slowed the NPC cell proliferation (Fig. 2B and C). This evidence concerns the gene PCBP2-OT1 and nasopharyngeal carcinoma.