While perturbation of the NR2B-PSD-95 interaction in the spinal cord reportedly attenuates thermal and mechanical pain hypersensitivity induced by either nerve injury, malignant tumors, or diabetes, no obvious difference was found between the two types of nociception with those manipulations, suggesting that spinal NR2B and PSD-95 play similar roles in this two noxious stimuli-induced pain hypersensitivity22,33,34. This evidence concerns the gene GRIN2B and cancer.