INS and obesity due to melanocortin 4 receptor deficiency: Silybum Marianum has lipid-lowering, antihypertensive, antidiabetic, anti-atherosclerotic, hepatoprotective, and anti-obesity effects and is known for its antioxidant, anti-inflammatory, and β-cell regenerative effect; enhancement of insulin sensitivity; and inhibition of gluconeogenesis and Glut4-mediated transport37.