To evaluate the implication of miR-223-3p in the polarization of macrophages and the regulation of inflammatory response, we performed transient inhibition experiments by intranasal instillation to male and female mice of an antagomiR-223, or anti-scrambled RNA as a control, 30 min before GBS challenge and we measured the level of CD80, Arg1, IL-1β and IL-10 expression within the lungs at 6 h pi, time at which most innate inflammatory parameters reach their peak23. Here, ARG1 is linked to Guillain-Barre syndrome.