BCL2 and cancer: Using qPCR assay for known genes modulated NT157 in other cancer models9,26,27, we identified that NT157 decreased expression of oncogenes BCL2, CCND1, MYB, and MYC and increased genes related to cellular stress and apoptosis, JUN, BBC3, CDKN1A, CDKN1B, FOS, and EGR1 (all p < 0.05, Fig. 5).