SCN10A and myeloid sarcoma: For instance, hereditary demyelinating neuropathy leads to an upregulation of Scn10a/Nav1.8 and abnormal axonal excitability [53], and ectopic Scn10a/Nav1.8 is observed in the cerebellum of the experimental autoimmune encephalomyelitis (EAE) mouse model of multiple sclerosis (MS) and in MS patients [54].