Studies using scavenger receptor class B type I knockout and apolipoprotein E (apoE) knockout mice models have demonstrated that hypercholesterolemia impairs cholesterol homeostasis and stimulates the proliferation of hematopoietic stem and progenitor cells (HSPCs), resulting in myeloid expansion and the progression of atherosclerosis6,7. Here, APOE is linked to Hypercholesterolemia.