A personal or family cancer history increases the risk of breast, colorectal, gastric, and bladder cancer4–9, which includes the genetic disorders such as BRCA1/2, BRAF, KRAS, and p53. In the previous studies, 30–40% of sarcoma patients had a first-degree relative with a history of cancer (i.e., breast cancer, lung cancer); however, the histological types of sarcoma are not specified due to the relatively small study population10–12. The gene discussed is TP53; the disease is cancer.