MSH6 and undifferentiated pleomorphic sarcoma: Lynch syndrome is also associated with a personal or family history of colorectal cancer, in addition to the occurrence of certain types of sarcoma, such as undifferentiated pleomorphic sarcoma (UPS) and bone tumor, and this syndrome occurs because of microsatellite instability and/or the deletion of mismatch repair genes of MLH1, MSH2, MSH6, and PMS215,16.