ANXA2 and cancer: Though normal prostate epithelial cells express ANXA2 abundantly, it is not oncogenic, but in PCa, the constitutively active Src phosphorylates ANXA2's tyrosine-23 residue, which is critical for ANXA2 membrane translocation and all cancer-related functions such as plasminogen activation, actin-cytoskeletal rearrangement, cellular migration, adhesion, and proliferation7–13.