Regarding EGFR-mediated control of tensile Rac1 activity, ERK/MAPK signalling has been implicated to drive the overexpression and activation of the Rac-GEF in BRAF- and NRAS-mutant melanoma, as well as in KRAS- and EGFR- mutant lung cancer58,59. This evidence concerns the gene AKT1 and melanoma.