We then explored the role of ARF6 in tumor growth and found that knocking down ARF6 significantly inhibited the proliferation of WT EGFR cells, A549 cells (Fig. 6e), and MDA-MB-231 (Supplementary Fig. 6c), as well as EGFR mutant cells, PC9 and H1975 cells (Supplementary Fig. 6d, e). Here, EGFR is linked to neoplasm.