Using another mouse model, based on pancreas-specific KrasG12D oncogenic mutation but heterozygosity of the Trp53 null allele (Trp53het), the loss of Grem1 in already established PDAC tumours resulted in significantly higher numbers of liver and lung metastases compared to Grem1wt control mice, supporting an important role of Grem1 in suppression of metastasis formation via EMT. This evidence concerns the gene GREM1 and neoplasm.