Finally, it needs to be mentioned that TGFβ plays a major role also with regard to cellular plasticity for both, the pancreatic cancer cells and the surrounding microenvironmental cells, which has not been touched upon by the current study.6 For example, TGFβ not only drives EMT of PDAC cells in collaboration with Kras, but is also a major profibrogenic driver of the characteristic desmoplasia as well as a major immunosuppressive factor. The gene discussed is TGFB1; the disease is familial pancreatic carcinoma.