GREM1 and pancreatic neoplasm: A recent publication in Nature by Lan et al., presented GREM1 (gremlin 1) as an important regulatory node of cellular plasticity in pancreatic ductal adenocarcinoma (PDAC).1 Knockout experiments in mice point to an important role of Grem1 in retaining an epithelial, differentiated phenotype of pancreatic cancer cells presumably by inhibiting BMP signalling.