Our findings are consistent with those of several previous studies showing that EBD and albumin extravasation is substantially increased but that the extravasation of Ig or small molecules is only moderately increased or not increased in the early phases in preclinical stroke models (Olsson et al., 1971; Belayev et al., 1996; Aoki et al., 2002; Fernández-López et al., 2012; Jackman et al., 2013; Knowland et al., 2014; Liu et al., 2017). The gene discussed is ALB; the disease is Stroke.