BRCA1 and neoplasm: These observations were replicated in a different K14-Cre BRCA1f/fp53f/f tumor model on the FVB/N background (Figure S3D), and, interestingly, a trend toward such reprogramming was observed in a third model with BRCA1 proficiency (K14-Cre BRCA1wt/wtp53f/wt; Figure S3E).