PSEN1 and frontotemporal dementia: A patient with a familial history of early‐onset frontotemporal lobar degeneration carried the PSEN‐1 M146V mutation; the post‐mortem neuropathological study disclosed β‐amyloid plaques, NFTs, Pick bodies in the hippocampus and cortex, cortical globose tangles, and ubiquitin‐positive nuclear inclusions in white matter oligodendrocytes [40].