The dysregulation of a few cell cycle regulators, such as Aurora-A kinase (AurA), Polo kinase (Polo), and Serine/Threonine protein phosphatase 2A (PP2A) results in disruption to NSC asymmetry and microtubule functions, leading to NSC overgrowth and brain tumor formation [27,29,35,37–43]. This evidence concerns the gene AURKA and brain neoplasm.