After adjusting for age, sex, BMI, creatinine, and medical history of hyperlipidemia, hypertension, and DM, plasma irisin levels remained significantly different between patients with massive aortic valve calcification and no aortic valve calcification (OR = 0.158, 95% CI 0.060–0.415, P < 0.001). This evidence concerns the gene FNDC5 and Hypertension.