FNDC5 and aortic valve calcification: After adjusting for age, sex, BMI, creatinine, and medical history of hyperlipidemia, hypertension, and DM, plasma irisin levels remained significantly different between patients with massive aortic valve calcification and no aortic valve calcification (OR = 0.158, 95% CI 0.060–0.415, P < 0.001).