This is supported by the role of tenascin-C as an important molecule promoting migration and invasion both in vitro and in vivo, and knockdown of tenascin-C in CRC cells significantly suppressed their proliferation and impaired their migration and invasion.38 Overall, upregulated expression of tenascin-C plays a major role in cancer progression, and metastasis and may result in a poor prognosis for CRC patients. This evidence concerns the gene TNC and colorectal carcinoma.