We found that, while knockdown of RNF146 did not affect normal tissue growth (Figure 5—figure supplement 4A and B, quantified in Figure 5—figure supplement 4C), it significantly suppressed RasV12/dlg-/- tumor growth (Figure 5H–J, quantified in Figure 5K) and promoted elimination of dlg-/- clones (Figure 5—figure supplement 4D and E, quantified in Figure 5—figure supplement 4F). This evidence concerns the gene RNF146 and neoplasm.