RNF146 and neoplasm: Furthermore, although overexpression of RNF146 did not affect RasV12/dlg-/- tumor growth (Figure 5L–M, quantified in Figure 5N), overexpression of RNF146 weakened the tumor-suppressive effect of miR-306 or miR-79 on RasV12/dlg-/- tumors (Figure 5O–R, quantified in Figure 5S).