DIO3OS and malignant colon neoplasm: FMO6P was found to be associated with the prognosis of squamous cell lung carcinoma patients [34], SDHAP1 could promote the apoptosis of ovarian cancer [35], C9orf163 was associated with the prognosis of pancreatic cancer patients [36], DIO3OS could regulate the occurrence and development of liver, thyroid, and pancreatic cancer [37, 38, 39], and ZDHHC8P1 was able to promote the progression of colon cancer [40].