The increased levels of NF‐κB (IL1α, IL1β, and TNF‐α) and IFN (MX1, IFIT1, and ISG15) dependent cytokine response in Irgm1−/− mice colon were suppressed by treatment of GSK583 in both shigellosis‐ and DSS‐induced colitis models (Figs 7F and EV5G). Here, ISG15 is linked to colitis.