Additional analysis and functional study of susceptibility loci will be needed to comprehensively and accurately reveal the relationship between CARD14 gene polymorphisms and psoriasis vulgaris and to further explore the impact of CARD14 gene SNPs on the pathogenesis and severity of psoriasis and the role in the stimulation of NF-κB that may lead to psoriasis vulgaris. The gene discussed is NFKB1; the disease is psoriasis.