CARD14 and psoriasis: The majority of genes of innate immunity belong to this pathway including the caspase recruitment domain family member 14 (CARD14) gene.[11,18] Previous study has shown that the CARD14 gene, also known as Bimp2 or CARMA2, found at chromosome 17q25 in psoriasis susceptibility locus 2, is associated with psoriasis.[20] In healthy skin, CARD14 is primarily abundant in placenta and keratinocytes of the basal layer of the epidermis, compared to psoriatic skin lesions that have increased levels of CARD14 in the upper layers of the epidermis and reduced CARD14 levels in the basal layer.[21]