CARD14 and psoriasis vulgaris: Moreover, through NF- κB luciferase reporter assay, it was reported to upregulate the effect of NF-κB > 2 times as well as lead to stimulation of psoriasis-related genes.[23] Later, a Japanese cohort also associated rs144475004 as a potential risk for GPP with psoriasis vulgaris, (P = .01; OR 8.62; 95% 1.75~42.4; power calculation of 0.609).[28] Berki et al reported that this SNP leads to increased oligomerization of CARD14 gene and thereby increased association with GPP in Asian population (P = 8.4 × 10 − 5; OR = 6.4), but not associated with psoriasis vulgaris alone.