This finding was pronounced when this SNP was conditioned on psoriasis susceptibility locus 1.[23] Additionally the same risk allele, was also associated with psoriasis (P = .03) in Asians.[24,41] These results were further validated by Shi et al meta-analysis.[48] Meanwhile, Judith et al found a couple of CARD14 gene variants (rs117918077, rs2066964, rs28674001, and rs11652075) in a Hungarian patient with childhood-onset PRP that worsened in adulthood, whose lesions were unresponsive to retinoic acid treatment. Here, CARD14 is linked to familial pityriasis rubra pilaris.