Sepsis-associated encephalopathy (SAE) is a poorly understood acute cerebral dysfunction that appears in the setting of sepsis and septic shock, affecting as many as 71% of patients.[8] As an indicator of sepsis, diagnosis of SAE occurs primarily through the detection of abnormalities in electroencephalogram recordings and abnormal mental status, along with clinical history, physical examination, laboratory tests, and neuroimaging evaluation.[9] Neuron-specific enolase (NSE) is a glycolytic enzyme mainly expressed in neurons and glial cells. The gene discussed is ENO2; the disease is Sepsis.