Liang Mingzhan et al[21] proved through network pharmacological research that the drug combination of rehmannia glutinosa-radix polygoni multiflori preparata-acorus tatarinowii schott-rhizoma Chuanxiong regulates the pathways related to neurodegenerative diseases and inflammatory vascular diseases acts on the endocrine system and nervous system and plays a role in the treatment of VaD through the way of tonifying the kidney and with the help of key targets such as APP, TNF, and JUN. Here, TNF is linked to neurodegenerative disease.