JUN and neurodegenerative disease: Liang Mingzhan et al[21] proved through network pharmacological research that the drug combination of rehmannia glutinosa-radix polygoni multiflori preparata-acorus tatarinowii schott-rhizoma Chuanxiong regulates the pathways related to neurodegenerative diseases and inflammatory vascular diseases acts on the endocrine system and nervous system and plays a role in the treatment of VaD through the way of tonifying the kidney and with the help of key targets such as APP, TNF, and JUN.